14-3-3 proteins regulate desmosomal adhesion via plakophilins
نویسندگان
چکیده
منابع مشابه
The 14-3-3 proteins positively regulate rapamycin-sensitive signaling
BACKGROUND The kinase Tor is the target of the immunosuppressive drug rapamycin and is a member of the phosphatidylinositol kinase (PIK)-related kinase family. It plays an essential role in progression through the G1 phase of the cell cycle. The molecular details of Tor signaling remain obscure, however. RESULTS We isolated two Saccharomyces cerevisiae genes, BMH1 and BMH2, as multicopy suppr...
متن کاملThe 14-3-3 proteins
So what’s so interesting about them? In 1996 14-3-3 was found to bind to a variety of oncoproteins including Raf-1, polyoma middle T, and Bcr-Abl. Since then the 14-3-3 proteins have been shown to bind to a wide variety of proteins involved in signal transduction, cell cycle and apoptosis. These proteins include Cdc25, NFAT, Bad, Cbl, A20, PI 3-kinase, IRS-1, MEKK, p130Cas, glucocorticoid recep...
متن کاملStratifin (14-3-3 σ) Limits Plakophilin-3 Exchange with the Desmosomal Plaque
Desmosomes are prominent cell-cell adhesive junctions in stratified squamous epithelia and disruption of desmosomal adhesion has been shown to have dramatic effects on the function and integrity of these tissues. During normal physiologic processes, such as tissue development and wound healing, intercellular adhesion must be modified locally to allow coordinated cell movements. The mechanisms t...
متن کامل14-3-3 proteins in apoptosis.
The once obscure members of the 14-3-3 protein family play significant roles in the determination of cell fate. By inhibiting the pro-apoptotic BAD (Bcl-2-antagonist of cell death) and the transcription factor FKHRL-1, 14-3-3 displays important anti-apoptotic characteristics. To date, five points of interaction of 14-3-3 with the apoptotic machinery have been identified. How these interactions ...
متن کامل14-3-3 proteins regulate Tctp-Rheb interaction for organ growth in Drosophila.
14-3-3 family proteins regulate multiple signalling pathways. Understanding biological functions of 14-3-3 proteins has been limited by the functional redundancy of conserved isotypes. Here we provide evidence that 14-3-3 proteins regulate two interacting components of Tor signalling in Drosophila, translationally controlled tumour protein (Tctp) and Rheb GTPase. Single knockdown of 14-3-3ɛ or ...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2018
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.212191